The majority of the socioeconomic disparity, or deprivation gap, in cancer incidence could have been prevented in England between 2013 and 2017 if nobody had smoked, according to a new study published September 21 in the open-access journal PLOS ONE by Nick Payne of Cancer Research UK and colleagues.

Smoking is the main cause of preventable cancer and death in the UK, accounting for around 15% of all cancer cases in England in 2015. Cancer incidence also varies by socio-economic position across the UK, with the overall cancer incidence rate 17% higher in the lowest-income quintile of the population compared with the highest in England.

In the new study, the researchers focused on the 15 cancer types with strong evidence for an association with smoking — which contribute over 8 in 10 deprivation-associated cancer cases in England. Smoking-attributable cancer cases in 2013-17 were calculated by combining cancer incidence with smoking prevalence (in 2003-07, allowing for the lag between smoking and cancer diagnosis) and relative risk of being diagnosed with cancer among smokers vs non-smokers. These smoking-attributable cases were then shown as a proportion of the deprivation-associated cancer cases total.

The study found that 21.1% of cancer cases in the most deprived quintile of the population could be attributed to smoking, but only 9.7% of cancers in the least deprived quintile could be attributed to smoking — a difference of nearly 2.2-fold. If everyone had the same smoking prevalence as the least deprived quintile, 20.3% of deprivation-associated cancers, or more than 5,000 cases each year, could have been prevented. If nobody smoked at all, 61% of deprivation-associated cancer incidence, or more than 16,000 cases each year, could have been prevented. Among cancer types, the fraction of cases attributable to smoking was highest for lung, larynx, pharynx, bladder, and oesophageal squamous cell carcinoma.

The authors conclude that tobacco control policies that tackle smoking inequalities could prove cost-effective given their impact in reducing smoking-related ill-health, including cancer rates.

The authors add: “This study is the first of its kind to quantitively assess the contribution of smoking to deprivation-associated cancer incidence in England. The findings help to confirm that smoking is the key driver of cancer incidence inequalities in England, therefore policy measures should continue to bring down smoking prevalence with a specific focus on the most deprived populations.”



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