Development of a global innovative drug in eye drop form for treating dry age-related macular degeneration
Schematic representation of the construction and screening of a large-scale peptide library targeting TLR signaling proteins, followed by efficacy validation in cellular and animal models. Credit: Korea Institute of Science and Technology

Age-related macular degeneration (AMD) is the leading cause of vision loss in individuals over 65, characterized by abnormal changes in the macular, resulting in reduced vision and distorted objects. Dry AMD accounts for 90% of all AMD cases, with relatively mild vision impairment; however, approximately 30% progress to the severe vision loss associated with wet AMD within 10 years.

The only FDA-approved treatments for dry AMD as of 2023 are two injectable drugs, which are limited by concerns over complications from intravitreal injections and modest efficacy in restoring vision.

A research team led by Dr. Moon-Hyeong Seo from the Natural Product Drug Development Center at the Korea Institute of Science and Technology (KIST) has developed a new therapeutic agent for dry AMD that can be administered as eye drops. The work is published in the journal Advanced Science.

Eye drops are the most preferred drug delivery method in the ophthalmic market, yet developing eye drop formulations targeting the retina, located in the posterior segment of the eye, remains a significant challenge.

To address the limitations of injection-based treatments, the research team focused on the inflammatory signaling pathway of Toll-like receptors (TLRs), which are known to play a critical role in AMD pathogenesis.

By extracting peptide sequences from tens of thousands of proteins with structures similar to natural TLR signaling proteins, they established an extensive library of over 190,000 peptide drug candidates.

Utilizing advanced technology for rapidly screening peptides that specifically bind to TLR signaling proteins, they successfully identified multiple candidate peptides capable of inhibiting interactions between these proteins.

Development of a global innovative drug in eye drop form for treating dry age-related macular degeneration
(A) Evaluation of therapeutic effects by administering the peptide as eye drops to mice with induced dry AMD. (B) In control mice with AMD, black drusen accumulation and atrophy and deformation of the retinal pigment epithelium were observed. In contrast, peptide-treated mice showed retinal protection comparable to normal mice. Credit: Korea Institute of Science and Technology

The researchers validated the therapeutic efficacy of the peptides by administering them as eye drops to mice with induced dry AMD. The treated group exhibited retinal cell protection and significantly reduced retinal degeneration, comparable to normal mice. This demonstrated that peptide-based eye drops could effectively replace existing injectable therapies for dry AMD.

This new therapeutic agent, delivered in eye drop form, offers enhanced treatment convenience and adherence for patients while reducing complications and costs associated with repetitive invasive treatments.

Furthermore, the non-invasive and safe nature of the therapy provides a novel treatment option that improves both efficacy and patient satisfaction. This innovation is expected to revolutionize the treatment accessibility of AMD and other related ophthalmic conditions.

Dr. Seo stated, “The KIST Natural Product Drug Development Center, established in September to focus on mission-driven research, aims to develop global drugs targeting aging-related diseases, including cancer and ophthalmic conditions. We plan to pursue collaborative research with domestic and international pharmaceutical companies to advance global clinical trials for this innovative dry AMD therapeutic.”

More information:
Yun Lim et al, Massively Parallel Screening of Toll/Interleukin‐1 Receptor (TIR)‐Derived Peptides Reveals Multiple Toll‐Like Receptors (TLRs)‐Targeting Immunomodulatory Peptides, Advanced Science (2024). DOI: 10.1002/advs.202406018

Citation:
Peptide-based eye drops show promise in treating age-related macular degeneration (2024, December 23)
retrieved 23 December 2024
from https://medicalxpress.com/news/2024-12-peptide-based-eye-age-macular.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.





Source link

Leave a Reply

Your email address will not be published. Required fields are marked *

Before you post, please prove you are sentient.

What color is the sky on a sunny day?

Explore More

Diabetes drug linked to increased risk of severe eye condition

Credit: CC0 Public Domain Two independent studies from the University of Southern Denmark (SDU) show that patients with type 2 diabetes who are treated with the drug Ozempic have an

Just a moment…

Just a moment… Enable JavaScript and cookies to continue This request seems a bit unusual, so we need to confirm that you’re human. Please press and hold the button until

Ground squirrel study points to potential development of a cataract drug

GS lens opacity is reversed during the hypothermia-rewarming cycle. Credit: Journal of Clinical Investigation (2024). DOI: 10.1172/JCI169666 Researchers at the National Institutes of Health (NIH) and their collaborators have identified