Immune activation in a pregnant woman can have negative effects on the development of fetal brain microglia — or macrophage immune cells in the brain — and even lead to neurodevelopmental disorders in newborns.

It’s not possible to monitor how microglia are developing within the fetal brain, but new research indicates that the health of fetal macrophages in the placenta can act as an indicator of the health of fetal brain microglia.

The research was led by investigators from Massachusetts General Hospital, a founding member of the Mass General Brigham healthcare system, and is published in Cell Reports.

“If we can use fetal placental macrophages as a surrogate cell type or biomarker for fetal brain microglial programming, we have the opportunity to identify those children at greatest risk from in utero immune-activating exposures. Identifying these children early creates the potential to intervene during key developmental windows to ameliorate the impact of those pregnancy exposures,” said senior author Andrea Edlow, MD MSc, an associate professor of Obstetrics, Gynecology, and Reproductive Biology, and a Maternal-Fetal Medicine specialist at Massachusetts General Hospital. Dr. Edlow is also an MGH Research Scholar.

Examples of immune-activating exposures during pregnancy include bacterial and viral infections, metabolic inflammation from obesity and diabetes, environmental toxins and maternal stress. Edlow and her colleagues assessed placental macrophages in a mouse model of maternal diet-induced obesity.

Single-cell RNA sequencing of mouse fetal placental macrophages (or Hofbauer cells) revealed similar gene expression signatures as fetal brain microglia during normal conditions and also in response to maternal diet-induced obesity.

Interestingly, the sex of the fetus impacted how maternal obesity affects the placenta and the fetal brain. Specifically, male placental macrophages and fetal brain microglia had a greater number of genes dysregulated by maternal obesity and more neuroinflammatory signaling than female cells.

When the investigators compared their mouse data with published human datasets, they found conserved gene expression patterns in placental macrophages in mice and humans, suggesting that their findings in mice may have clinical implications in humans.

“This work is a promising start for using fetal placental macrophages as a biomarker for fetal brain microglial programming in a variety of maternal exposures, and it could form the basis for creating personalized fetal models of neurodevelopment using cells from the placenta that are easily accessible at birth,” said Edlow.



Source link

Leave a Reply

Your email address will not be published. Required fields are marked *

Before you post, please prove you are sentient.

What is 5 times 8?

Explore More

Study demonstrates efficacy of iron supplements for children living with HIV

A University of Minnesota Medical School research team has found that giving iron supplements to children living with human immunodeficiency virus (HIV) in sub-Saharan Africa could be an important first

Serious eating disorder ARFID is highly heritable, according to new twin study

ARFID is strongly influenced by genetic factors, according to a twin study examining this relatively new type of eating disorder. The study has been published in the journal JAMA Psychiatry

High levels of omega-3, omega-6 may protect against cancer

In addition to lowering your cholesterol, keeping your brain healthy and improving mental health, new research from the University of Georgia suggests omega-3 and omega-6 fatty acids may help ward