Excessive prenatal prednisone exposure leads to chondrodysplasia in female offspring, osteoarthritis risk

PPE can lead to chondrodysplasia and increase susceptibility to adult OA in female offspring. Intrauterine Pred (rather than prednisone) exposure activated glucocorticoid receptor (GR) and recruited DNMT3B, resulting in DNA

Scientists discover a compound that could supercharge aging muscle repair

Skeletal muscle often begins to deteriorate relatively early in the aging process. Over time, this can cause loss of strength, increased scarring, fat buildup within muscle tissue, and a decline

A cellular community in the brain drives Alzheimer’s disease

An analysis of more than 1.6 million brain cells from older adults has captured the cellular changes that occur in the early stages of Alzheimer’s disease, potentially revealing new routes