A research team at the Korea University College of Medicine has uncovered a genetic mechanism responsible for delayed tooth development and impaired mineralization. The team, led by Professor Hae-chul Park (Department of Biomedical Sciences, Korea University College of Medicine) and Professor Ji-suk Shim (Department of Dentistry, Korea University College of Medicine), investigated the role of the Axin2 gene, which encodes a negative regulator of the Wnt/β-catenin signaling pathway—a critical pathway that orchestrates cell proliferation, differentiation, and organogenesis.
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Gene behind delayed, softer teeth found in zebrafish study
January 29, 2026
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